Influence of the neural microenvironment on prostate cancer

نویسندگان

  • Christian Coarfa
  • Diego Florentin
  • NagiReddy Putluri
  • Yi Ding
  • Jason Au
  • Dandan He
  • Ahmed Ragheb
  • Anna Frolov
  • George Michailidis
  • MinJae Lee
  • Dov Kadmon
  • Brian Miles
  • Christopher Smith
  • Michael Ittmann
  • David Rowley
  • Arun Sreekumar
  • Chad J Creighton
  • Gustavo Ayala
چکیده

BACKGROUND Nerves are key factors in prostate cancer (PCa), but the functional role of innervation in prostate cancer is poorly understood. PCa induced neurogenesis and perineural invasion (PNI), are associated with aggressive disease. METHOD We denervated rodent prostates chemically and physically, before orthotopically implanting cancer cells. We also performed a human neoadjuvant clinical trial using botulinum toxin type A (Botox) and saline in the same patient, before prostatectomy. RESULT Bilateral denervation resulted in reduced tumor incidence and size in mice. Botox treatment in humans resulted in increased apoptosis of cancer cells in the Botox treated side. A similar denervation gene array profile was identified in tumors arising in denervated rodent prostates, in spinal cord injury patients and in the Botox treated side of patients. Denervation induced exhibited a signature gene profile, indicating translation and bioenergetic shutdown. Nerves also regulate basic cellular functions of non-neoplastic epithelial cells. CONCLUSION Nerves play a role in the homeostasis of normal epithelial tissues and are involved in prostate cancer tumor survival. This study confirms that interactions between human cancer and nerves are essential to disease progression. This work may make a major impact in general cancer treatment strategies, as nerve/cancer interactions are likely important in other cancers as well. Targeting the neural microenvironment may represent a therapeutic approach for the treatment of human prostate cancer.

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عنوان ژورنال:

دوره 78  شماره 

صفحات  -

تاریخ انتشار 2018